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2-Chloro-5-(Chloromethyl)Pyridine: Properties, Applications, and Safety Guide

  What Is 2-Chloro-5-(Chloromethyl)Pyridine? 2-Chloro-5-(Chloromethyl)Pyridine  is a pale-yellow liquid compound. It features a pyridine ring substituted with chlorine at the second position and a chloromethyl group at the fifth position. This compound has the molecular formula C6H5Cl2N. It's widely used in organic synthesis, especially in the pharmaceutical and agrochemical industries. Key Chemical Properties Molecular Formula: C6H5Cl2N Molecular Weight: 162.02 g/mol Boiling Point: Approx. 220 °C Density: ~1.31 g/cm³ Appearance: Pale-yellow to colorless liquid Solubility: Slightly soluble in water; soluble in most organic solvents This compound exhibits high reactivity due to the electron-withdrawing chlorine atoms on the pyridine ring. Its structure enables selective substitution and alkylation reactions. Major Applications in Industry 1. Pharmaceutical Intermediate 2-Chloro-5-(Chloromethyl)Pyridine is used to synthesize active pharmaceutical ingredients (APIs). It serves as...