Picoxystrobin is a fungicide that is used by many farmers internationally to help improve yields and prevent costly diseases. Picoxystrobin is a highly successful methoxyacrylate product and is now the world's largest selling fungicide active with sales of over $1 billion. This fungicide is part of the strobilurin chemical family. Picoxystrobin, written chemically as C18H16F3NO or Methyl (E)-3-methoxy-2-[2-(6-trifluoromethyl-2-pyridyloxymethyl)-phenyl]acrylate, was first sold in 2001. Synthetic chemists at Zeneca Agrochemicals first became interested in coccolithophores in the early 1980s. An extensive research programme was initiated with the aim of preparing analogues of natural products with high activity and physical properties suitable for agricultural fungicides. After the synthesis of some 1400 analogues, this effort culminated in the discovery of Picoxystrobin in 1988. After extensive biological characterisation, Picoxystrobin was selected for development as a new